КУРКУМИН ЗА ВЪНШНО ПРИЛОЖЕНИЕ –ПРЕДИЗВИКАТЕЛСТВА, РЕШЕНИЯ И ПЕРСПЕКТИВИ
CURCUMIN FOR EXTERNAL APPLICATION -CHALLENGES, SOLUTIONS AND PROSPECTS

Summary/Abstract: Turmeric is a spice that is widely used in cooking, but is becoming increasingly important in medicine and pharmacy, causing more and more in-depth studies of its action and uses. The main active ingredient in this herb is curcumin, whose polyphenolic structure determines its anti-inflammatory, antioxidant and cholekinetic effect. These properties of curcumin determine its wide application, and in the present review we have focused on dosage forms suitable for external use. It is known that the main difficulty in the preparation of formulations containing curcumin is its low solubility. For this reason, in our work we consider various methods used in pharmaceutical technology to solve this problem. Most often in recent years, various nanostructured carriers have been used to incorporate curcumin into a dosage form. In the review we consider its application as an active ingredient that helps heal wounds. When applied to the skin, curcumin shows promising results in wounds caused by the development of diabetes, as well as in burns. Various semi-solid dosage forms containing curcumin - pastes, hydrogels, etc. have been used in studies in the treatment of melanoma. These studies indicate that the use of solid lipid nanoparticles, polymer nanoparticles, micelles and liposomes has been tested to increase the solubility and bioavailability of curcumin. This in turn makes it possible to conduct experiments in which it was found that these dosage forms can be used both for the treatment and prevention of skin malignancies. Psoriasis is one of the most common skin diseases. Studies show that the use of curcumin-containing formulations affects psoriatic plaques, which is a prerequisite for the more in-depth development of such products. Curcumin is also indicated for skin lesions caused by radiation therapy. It can also be used for onychomycosis, dermatitis and others. In our review, we also consider the possibilities of using curcumin-containing dosage forms in ophthalmology. There is evidence of a positive effect of curcumin included in semi-solid dosage forms in glaucoma. Curcumin preparations can also be used for oral mucositis, oral lichen planus, for use in the nose, as well as for some vaginal bacterial infections. Our literature review on the topic shows that more and more solutions are being found to the problems we had until recently in the widespread use of curcumin. This in turn gives new and new perspectives in the treatment of various diseases.

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