A SIMPLE EDUCATIONAL TOOL FOR MATHEMATICAL MODEL OF SKIN ABSORPTION FOR BIOMEDICAL ENGINEERING STUDENTS
A SIMPLE EDUCATIONAL TOOL FOR MATHEMATICAL MODEL OF SKIN ABSORPTION FOR BIOMEDICAL ENGINEERING STUDENTS

Summary/Abstract: Biomedical Engineering (BME) is different from other engineering or medical areas, in the sense that the results are obtained usually by experimental procedures and the simulation using mathematical approaches are familiar to them without a very deep knowledge of medical subjects specific to physicians. The tool proposes one and two compartment models for mathematical model of skin absorption selected from models in literature. The compartments models are described by system of differential equations that are solved by numerical methods. The user has the possibility to select the model and the parameters of the models (the Graphical User Interface - GUI) is automatically updated according the selected model along with a graphical image of compartments and the variables that are assigned to interaction among compartments. The parameter for simulation (the solving of system of differential equations) are adjusted optimally according to selected model but they can be also modified by the user in order to test the sensitivity of the models to different value of parameters. The dosage substrate and/or inhibitors can be calculated by user using this tool. The constant of permeability and diffusion, deduced by experimental data, can be included and saved for future use using a selection panel. The implementation is made as a Matlab application with a GUI designed as a friendly user interface. The graphic of evolution of variable are displayed in a window, and the user has the possibility to select the group of variables to be visualized. The tool is accompanied by a small user's manual with a set of practical tests in the form of laboratories in order to improve the e-learning process. A more concise form of the mathematical model can be used by students in Balneo-Physio-Kinetotherapy (BFKT) by simulated be the Sulphur absorption by skin in sludge therapy.

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