Neuropsychic disorders and Sars-Cov-2 infections: a review
Neuropsychic disorders and Sars-Cov-2 infections: a review

Summary/Abstract: COVID-19 represents a severe multi-organ pathology that, in addition to the important cardio-respiratory damage, also affects the function of the central nervous system (CNS). Severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2), similar to other coronaviruses, significantly demonstrates neurotropism; viral infection of the brain can complicate the evolution of pathologies by disturbing the central cardio-respiratory control. Systemic inflammation, as well as the consequent neuroinflammatory changes, are associated with a massive increase in proinflammatory factors at the brain level, neuroglial hyperreactivity, important neurochemical disturbances, and pathological remodeling of the neural network. These multiple organic changes, which occur in accordance with the stress caused by hospitalizations in intensive care clinics, associated with pandemic-related phobias and sometimes abusively imposed social restrictions, promote neuropsychiatric pathologies, which can range from major depressive disorders, bipolar disorders (TB), various psychoses, obsessive-compulsive disorders and post-traumatic stress disorders. Therefore, the neuropsychiatric sequelae of COVID-19 represent an important clinical challenge that must be considered for future complex therapies.

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