SERUM LEVELS OF ADIPONECTINE AND LEPTIN IN GESTATIONAL DIABETES MELLITUS - REVIEW
SERUM LEVELS OF ADIPONECTINE AND LEPTIN IN GESTATIONAL DIABETES MELLITUS - REVIEW

Summary/Abstract: GESTATIONAL DIABETES MELLITUS (GDM) IS A METABOLIC COMPLICATION OF PREGNANCY. DUE TO THE EPIDEMY OF OVERWEIGHT AND OBESITY IN WOMEN AT REPRODUCTIVE AGE, PREVALENCE OF GDM IS INCREASING WORLDWIDE. GESTATIONAL DIABETES MELLITUS IS A PATHOLOGICAL STATUS CHARACTERIZED BY GLUCOSE INTOLERANCE WHICH IS ONSET OR FIRST RECOGNIZE IN PREGNANCY AND IS ASSOCIATED WITH SHORT AND LONG THERM MATERNO-FETAL COMPLICATIONS. UNDERSTANDING THE PHYSIOPATHOLOGY OF GDM IS AN IMPORTANT PROGRESS IN MANAGEMENT OF THESE CASES. BOTH MOTHER AND CHILD PRESENT A HIGH RISK OF DEVELOPING TYPE 2 DIABETES MELLITUS (T2DM), OBESITY AND METABOLIC SYNDROME LATER IN LIFE. GDM COVERS LATENT METABOLIC CHANGES THAT GENERATE A TRANSGENERATIONAL VICIOUS CIRCLE. INSULIN RESISTANCE AND β-CELL DYSFUNCTION ARE INVOLVED IN PATHOGENESIS OF GDM. OBESITY IS A RISK FACTOR OF DEVELOPING GDM. ADIPOSE TISSUE SECRETES ADIPOKINES INVOLVED IN PATHOPHYSIOLOGY OF GDM AND ALSO IN ENERGY HOMEOSTASIS, CARBOHYDRATE AND LIPID METABOLISM. THE PURPOSE OF THIS REVIEW WAS TO ANALYSIS SERUM ADIPOCYTOKINES LEVELS IN PREGNANCIES COMPLICATED WITH GESTATIONAL DIABETES.

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