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Summary/Abstract: As a colleague who has also been trained in biochemistry and molecular biology, I have long admired Jesper Hoffmeyer’s linguistic dexterity in expressing intricate concepts in plain language. And the above quote from his 2001 paper ‘Life and reference’ is even more cogent today. During the intervening decade, the success of molecular biology has been amplified manyfold. The manifold of biochemical relationships among the various ‘-omics’ created during this very productive decade has deluged us with data without substantially deepening our understanding of our origins.

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