Transcriptional and translational mechanisms diversifying the proteome
Transcriptional and translational mechanisms diversifying the proteome

Summary/Abstract: Results of genome sequencing show a surprising lack of a clear dependence between the number of genes and the organisms’ level of complexity. Moreover, along with proteomic data they indicate substantial disparity between the number of proteins and genes in Eukaryota. The resolution of this conundrum, along with post-translational modifications, may lie in mechanisms diversifying the proteome. Here, along with the most often cited examples such as alternative splicing, transcription initiation and termination, less common phenomena are described: RNA recoding, RNA editing, alternative translation initiation, and STOP codon readthrough.

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