Grelina – niewielki peptyd, WIELKIE możliwości
Ghrelin – small peptide, LARGE opportunities

Summary/Abstract: Ghrelin is a polypeptide-like hormone, synthesized mainly in stomach fundus and body by the neuroendocrine X/A cells. It works via GHS-R1a receptors, which are localized in numerous organs. Ghrelin secretion is multifactorial and depends on plenty of endo- and egzogenous conditions. As investigated, ghrelin is one of the most significant compounds taking part in human metabolism. It was nicknamed “the hunger hormone” after its role in appetite stimulation. Moreover, ghrelin interacts with carbohydrate and lipid metabolism, decreasing insulin secretion and intensifies adipogenesis process. Other functions of ghrelin are inter alia the anti-inflammatory effect, the role in osteogenesis process, alimentary and reproductive processes and its influence on the cardio-vascular system. It was also found that ghrelin is involved in positive impact on long-term and spatial memory.

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