NODOZNA BOLEST ŠTITNE ŽLIJEZDE: EVALUACIJA ULTRAZVUČNE METODE U DIFERENCIJACIJI BENIGNIH, SUSPEKTNO MALIGNIH I MALIGNIH TIREOIDNIH ČVOROVA
NODULAR THYROID DISEASE: ULTRASONOGRAPHY EVALUATION IN DIFFERENTIATION BENIGN, SUSPECTED MALIGNANT AND MALIGNANT THYROID NODULES

Summary/Abstract: The aim of this study was to determine the sensitivity (Se), specificity (Sp), positive (PPV) and negative predictive values (NPV) and diagnostic accuracy of ultrasonography in the evaluation of benign, suspected malignant and malignant thyroid nodules. Methods: This is a retrospective-prospective study of thyroid nodules in 155 patients, of both sexes, the average age of 56.34y132 (85,2%) females and 23 (14,8%) male. The subjects in this study were a specially selected group of patients who had been reffered to a surgeon to have an operation due to suspected cytological findings, the size of goiter or symptoms of compression. Based on ultrasound patterns, thyroid nodules are divided into 3 groups: benign, suspected malignant and malignant lesions. The preoperative ultrasound features of thyroid nodules were compared with postoperative histopathology results. For each tested group - Se, Sp, PPV, NPV and diagnostic accuracy were estimated. Results: The Se, Sp, PPV, NPV and overall diagnostic accuracy of ultrasound methods compared with histological findings in the evaluation of benign thyroid nodules were: 41,74%, 42,30%, 58,90%, 26,82% and 41,93%; in suspect malignant were: 29,50%, 93,61%, 75%, 67,17% and 68,38%; and in malignant thyroid lesions were: 33,87% 94,62%, 80,76%, 68,21% and 70,32%, respectively. Conclusion: The results of this study indicate that the ultrasound examination had high specificity and high PPV in detection suspect malignant and malignant thyroid nodules.

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