ПРОЯВЛЕНИЯ МЕТАБОЛИЧЕСКОГО СИНДРОМА У БОЛЬНЫХ МУЛЬТИФОКАЛЬ-НЫМ АТЕРОСКЛЕРОЗОМ
COMPONENTS OF THE METABOLIC SYNDROME AT PATIENTS WITH THE MULTI-FOCAL ATHEROSCLEROSIS

Summary/Abstract: The article is devoted to studying of components of a metabolic syndrome at patients with multifocal atherosclerosis (MFA). Changes of lipid’s, carbohydrate’s metabolism parameters, markers of a system inflammation and oxidizing stress are analyzed at patients with MFA, in-cluding atherosclerotic damage in various arterial pools (carotid, coronary, iliac-femoral) and it’s combinations. Materials and methods of research included the analysis of the clinic and la-boratory data at 84 patients with a peripheral and multifocal atherosclerosis. It is established, that at a peripheral atherosclerosis of the main arteries of a leg (AMAL) from components of metabolic syndrome (MS) most frequently observed hyperthreeglyceridemia without obesity. Ar-terial hypertension and hyperthreeglyceridemia observed at MFA, including carotid arteries damage; obesity and hypercholesterolemia were at patients with stenosis / occlusion of coro-nary and carotid arteries without atherosclerosis in iliac-femoral vessels. Presence of full clus-ter of MS observed in 60 % of cases at patients with damage of 3 arterial pools, whereas at pa-tients with AMAL ( damage of 1 arterial pool) it was only in 30 % of cases, that half is less, than at MFA. It specifies the high importance of adverse influence of MS components to MFA pro-gression. It was established, MFA, including carotid and coronary arteries it is accompanied by a high level of oxidizing stress, probably, due to the high sensitivity of brain and heart tissues to hypoxia and vulnerability from toxic effects of reactive oxygen species. At patients with coro-nary and carotids atherosclerosis the oxidizing stress was closely connected to an inflammation: correlation between C-reactive protein and malondialdehyde levels has made (r = 82, p > 0,05). For MFA, including coronary arteries damage the prevalence of oxidizing stress was es-tablished, at MFA with AMAL the inflammation was more expressed. Inflammation and oxidizing stress are factors of development and progressing of MFA.

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