Novel Heteroarylamino-Chromen-2-Ones and Their Antibacterial Activity
Novel Heteroarylamino-Chromen-2-Ones and Their Antibacterial Activity

Summary/Abstract: A series of heteroarylamino-chromen-2-ones 4(a-c) were synthesized by condensation reactions under catalytic conditions. 5-(3-Nitro-2-oxo-2H-chromen-4-ylamino)-3H-imidazole-4-carboxamide 4a, 4-(7-Hydroxy-5-methyl-[1,8]-naphthyridin-2-ylamino)-3-nitrochromen-2-one 4b and 4-(4-methylbenzothiazol-2-ylamino)-3-nitrochromen-2-ones 4(c-d) were synthesized by condensation of 4-chloro-3-nitrochromen-2-one 2 with corresponding heteroarylamines 3(a-d) under reflux reaction conditions. Alkali hydrolysis of compounds 4(a-d) afforded the 2-hydroxy-ω-nitroacetophenone 5. The structures of the obtained compounds were established on the basis of FTIR and NMR spectrometric data and their elemental analysis. Compounds of series 4(a-c) were screened for their antibacterial activity against S. aureus, E. coli and Klebsiella by Diffusion Disc Method. Compounds 4(a-c) displayed considerable activity against these microorganisms and the impact of substitutions in antimicrobial activity was also explored.

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