Nieszczelność jelit w chorobach autoimmunologicznych
Leaky gut syndrome in autoimmune diseases

Summary/Abstract: Leaky gut syndrome (LGS) is associated with increased permeability of the intestinalmucosa due to the destruction of its structure and associated abnormal function. Heterogeneous etiology includes infections, stress, pregnancy, diet, menopause, medication,and food allergies. The end result is damage and destabilization of the intestinal mucosa leading to loss of the ability to properly filter nutrients and other substances. As a result of increased intestinal permeability, incompletely digested nutrients, microbes and toxins that would be removed in normal conditions enter the bloodstream, thereby adversely affecting the whole organism. Chronic exposure to foreign antigens overloads the immune system. Finally, disorders of the digestive system may appear, resulting in chronic fatigue,food intolerances, joint pain and dermopathy. Dysregulation of the immune response in the course of LGS may finally lead to chronic autoimmune diseases including diabetes,systemic lupus erythematosus, Crohn’s disease, colitis, multiple sclerosis, Hashimoto’s disease, or rheumatoid arthritis (RA).

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