Зміни мембранних білків еритроцитів при безкам’яному холециститі та хворобі крона
Membrane erythrocyte proteins changes under noncalculous cholecystitis and crohn’s disease

Summary/Abstract: The aim of the investigation was to reveal the changes in erythrocytes’ proteins from human blood under gastroenterological pathologies, namely noncalculous cholecystitis and Crohn’s disease. The erythrocyte was used as a model system. The PAAG electrophoresis with SDSNa method was used. Erythrocyte membrane proteins quantitative changes were observed in patient groups under liver and intestines diseases. High molecular weight proteins content (spectrines α and β) was reduced, but any changes were not registered under the Crohn’s disease. Low molecular weight proteins content (anion-transporting protein and protein band 4.5) increased considerably as compared with a control (healthy people group). The structure of erythrocytes’ membrane changed, that led to disturbance of function of cytoskeleton proteins. The research results give more wide explanations of the pathologies genesis.

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