Ból neuropatyczny: etiologia, patomechanizm, implikacje kliniczne wynikające z badań podstawowych
Neuropathic pain: etiology, pathomechanism and clinical implications of the basic scientific research

Summary/Abstract: The nervous system damage resulting from mechanical injury, tumor, cancer, neurodegenerative diseases or diabetes frequently leads to the development of neuropathic pain. The main symptoms of painful neuropathy are allodynia (the unpleasant sensory feeling triggered by a stimulus which normally does not provoke pain) and hyperalgesia (pain hypersensitivity). Until these days neuropathic pain treatment has remained a huge clinical problem, mainly because of its complex and heterogeneous pathomechanism. Scientists have been looking for an effective drug with long-lasting effects. Recent studies suggested that neuroimmunological interactions between neurons, glial cells and immune cells mediated by pro- and anti-inflammatory factors, e.g. interleukins or chemokines and their receptors, are of key importance for the development of neuropathic pain. An increasing number of studies indicate that pharmacological modulation of glial cells as well as nociceptive factors, due to its beneficial effects, may become a new promising target for polytherapy of neuropathic pain.

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