A New Approach for the Synthesis of P-Anisyl Ethyl Fumarate: a C-9154 Antibiotic Analogue Cover Image
  • Price 2.00 €

A New Approach for the Synthesis of P-Anisyl Ethyl Fumarate: a C-9154 Antibiotic Analogue
A New Approach for the Synthesis of P-Anisyl Ethyl Fumarate: a C-9154 Antibiotic Analogue

Author(s): Maulidan Firdaus, Ahmad Ainurofiq, Aulia Vellarani
Subject(s): Social Sciences, Education, Vocational Education, Adult Education, Higher Education , Inclusive Education / Inclusion
Published by: Национално издателство за образование и наука „Аз-буки“
Keywords: p-anisaldehyde; p-anisyl ethyl fumarate; C-9154 antibiotic; solvent-free

Summary/Abstract: A simple, energy-efficient, and relatively quick synthetic procedure for the synthesis of p-anisyl ethyl fumarate from p-anisaldehyde has been carried out. The synthesis was started by solvent-free reduction of the aldehyde using sodium borohydrate. The second step was solvent-free condensation of the resulting alcohol with maleic anhydride to be followed by esterification of the resulting acid with ethanol in the presence of benzenesulfonic acid as the catalyst. Satisfactorily isolated yields (65-98%) were achieved confirming that the preparation of the C-9154 antibiotic analogue is possible in sustainable fashion.

  • Issue Year: 25/2016
  • Issue No: 6
  • Page Range: 874-880
  • Page Count: 7
  • Language: English