A New Approach for the Synthesis of P-Anisyl Ethyl Fumarate: a C-9154 Antibiotic Analogue
A New Approach for the Synthesis of P-Anisyl Ethyl Fumarate: a C-9154 Antibiotic Analogue

Summary/Abstract: A simple, energy-efficient, and relatively quick synthetic procedure for the synthesis of p-anisyl ethyl fumarate from p-anisaldehyde has been carried out. The synthesis was started by solvent-free reduction of the aldehyde using sodium borohydrate. The second step was solvent-free condensation of the resulting alcohol with maleic anhydride to be followed by esterification of the resulting acid with ethanol in the presence of benzenesulfonic acid as the catalyst. Satisfactorily isolated yields (65-98%) were achieved confirming that the preparation of the C-9154 antibiotic analogue is possible in sustainable fashion.

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