6,6’,8,8’-Tetrametyl-4,4’,7.7’-Tetrahydros-7,7’-Bi-1,2,4,5-Tetrazocine-3,3’(2h,2’h)-Dithione, a Novel Hydrazone Schiff Base with Promising Pharmacological Effects Cover Image
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6,6’,8,8’-Tetrametyl-4,4’,7.7’-Tetrahydros-7,7’-Bi-1,2,4,5-Tetrazocine-3,3’(2h,2’h)-Dithione, a Novel Hydrazone Schiff Base with Promising Pharmacological Effects
6,6’,8,8’-Tetrametyl-4,4’,7.7’-Tetrahydros-7,7’-Bi-1,2,4,5-Tetrazocine-3,3’(2h,2’h)-Dithione, a Novel Hydrazone Schiff Base with Promising Pharmacological Effects

Author(s): Manoj Kumar, Anita Rani, Rajshree Khare, Hardeep Singh Tuli, Sunil Arora, Rajendra Kumar
Subject(s): Social Sciences, Education, Other, Vocational Education, Adult Education, Higher Education , Scientifc Life, Inclusive Education / Inclusion
Published by: Национално издателство за образование и наука „Аз-буки“
Keywords: 3.4-diacetylhexane-2.5-dione; thiocarbohydrazide; antimicrobial activities; anti-angiogenesis; DNA-cleavage and anti-proliferation

Summary/Abstract: Novel hydrazone Schiff base viz. 6,6’,8,8’-tetramethyl-4,4’,7,7’- tetrahydro-7,7’-bi-1,2,4,5-tetrazocine-3,3’(2H,2’H)-dithionehas been synthesized from3,4-diacetylhexane-2,5-dione and thiocarbohydrazideandcharacterized. The bicyclichydrazone Schiff basehas been found active against bacteria[S.aureus and K.pneumoniaae] and fungi [A.niger and Trichophytonrubrum]. DNA photo-cleav¬age and antiangiogenic behavior of synthesized hydrazone Schiff base has been studied. Furthermore,the synthesizedhydrazone Schiff basesignificantly inhibited cell proliferation with IC50 value 62.5μg/ml. The flow-cytometry analysis of hy¬drazone Schiff base treated human breast cancer cells showed that apoptosis rate increased with increase in dose. In conclusion present study proposes the develop¬ment of novel therapeutic strategy for MCF-7 cancer cell treatment.

  • Issue Year: 28/2019
  • Issue No: 1
  • Page Range: 141-154
  • Page Count: 14
  • Language: English