Amperometric Nitric Oxide Sensor Based on MWCNT Chromium (III) Oxide Nanocomposite
Amperometric Nitric Oxide Sensor Based on MWCNT Chromium (III) Oxide Nanocomposite

Summary/Abstract: Multiwalled carbon nanotube and Chromium (III) oxide nanocomposite was used as a mediator in glassy carbon electrodes to improve the performance of electrode for the detection of nitric oxide in comparison with unmodified electrodes. The sensor could be operated as a detector in a flow injection analytical setup under physiological conditions (pH 7.5, 0.1 M phosphate buffer) with an operating potential from 800 mV (vs. Ag/AgCl), a flow rate of the carrier of 0.4 mL/min and an injection volume of 200 μL. The amperometric response of the sensor showed good linearity up to 200 µM with a sensitivity of about 21.6 nA/µM. The relative standard deviation for the repeatability of measurements for 100 µM NO was 3.9% (n = 10 measurements) and the reproducibility was 12% (n = 5 sensors). The effect of all investigated interferences (nitrite, ascorbic acid, dopamine and L-arginine) was not fatal and at 800 mV the signal ratio of NO/NO2- is around 10. The new sensor was successfully applied to the determination of NO in mice liver homogenisate after addition of L-arginine

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