Spectral, Biological, Magnetic and Conductance Studies on the Coordination Compounds of a Newly Synthesized Thiazolidin-4-One
Spectral, Biological, Magnetic and Conductance Studies on the Coordination Compounds of a Newly Synthesized Thiazolidin-4-One

Summary/Abstract: A dry benzene solution of the Schiff base, N-(2-hydroxyphenyl)-3‘-carboxy-2‘-hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N-(2-hydroxyphenyl)-C-(3‘-carboxy-2‘-hydroxyphenyl) thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with CoII and CdII ions and forms the monomeric coordination compounds, [Co(LH)(MeOH)3](II) and [Cd(LH)(MeOH)](III). The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance, NMR) studies and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are non-electrolytes (LM = 5.1-7.8 mho cm2 mol-1) in DMF. A tetrahedral structure for III and an octahedral structure for II are suggested. The ligand (I) and its coordination compounds shows antibacterial and antifungual activities towards bacteria, E. Coli. (Gram Negative) and S. Aureus (Gram Positive) as well as towards fungus, Candida Albicans. Keywords: thiazolidin-4-one, coordination compounds, magnetic susceptibility, magnetically dilute, strong field and covalent character

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