EFFECTS OF TIMOLOL AND ADRENALINE IN THE CONTROL OF CORNEAL NEOVASCULAR MOTILITY IN RATS
EFFECTS OF TIMOLOL AND ADRENALINE IN THE CONTROL OF CORNEAL NEOVASCULAR MOTILITY IN RATS

Summary/Abstract: THIS STUDY AIMED TO EVALUATE THE EXPRESSION OF ALPHA OR BETA-TYPE ADRENERGIC RECEPTORS IN CORNEAL NEW BLOOD VESSELS.THE EXPERIMENTS WERE PERFORMED ON WISTAR RATS, IN WHICH A MODEL OF CORNEAL NEOVASCULARIZATION WAS OBTAINED BY REPEATED INJECTIONS OF KETAMINE (150MG/KG BODY WEIGHT), ADMINISTERED INTRAPERITONEALLY. THE VARIATION OF THE EXTERNAL DIAMETER OF THE CORNEAL NEOFORMATION VESSELS WAS FOLLOWED, AT A TOTAL MAGNIFICATION OF APPROXIMATELY 400X, OVER 630 SECONDS. ADRENALINE PRODUCED STATISTICALLY SIGNIFICANT VASOCONSTRICTION IN THE CORNEAL NEOVESSELS VIA ALPHA-ADRENERGIC RECEPTORS. TIMOLOL PRODUCED STATISTICALLY SIGNIFICANT VASODILATION, REGARDLESS OF THE DOSE ADMINISTERED, BY A MECHANISM INDEPENDENT OF BETA-ADRENERGIC RECEPTORS. TIMOLOL CAUSED VASODILATION IN A DOSE-DEPENDENT MANNER, THE VASODILATION BEING INVERSELY PROPORTIONAL TO THE DOSE. FOLLOWING THESE RESULTS, WE CAN SAY THAT AT THIS LEVEL THERE ARE ALPHA-1 ADRENERGIC RECEPTORS, BUT WE CAN NOT EXCLUDE THE EXISTENCE OF BETA-ADRENERGIC RECEPTORS WHOSE STIMULATION PRODUCES VASODILATION.

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