EFFECTS OF TIMOLOL AND ADRENALINE IN THE CONTROL OF CORNEAL NEOVASCULAR MOTILITY IN RATS Cover Image

EFFECTS OF TIMOLOL AND ADRENALINE IN THE CONTROL OF CORNEAL NEOVASCULAR MOTILITY IN RATS
EFFECTS OF TIMOLOL AND ADRENALINE IN THE CONTROL OF CORNEAL NEOVASCULAR MOTILITY IN RATS

Author(s): Dana Damian, Aurelian Mihai Ghita, Ioana Cristina Coman, Sanziana Istrate, Magda GONCIAROV
Subject(s): Health and medicine and law
Published by: Research and Science Today
Keywords: ADRENALINE; TIMOLOL; NEW CORNEAL BLOOD VESSELS; CORNEA; VASOCONSTRICTION; VASODILATOR;

Summary/Abstract: THIS STUDY AIMED TO EVALUATE THE EXPRESSION OF ALPHA OR BETA-TYPE ADRENERGIC RECEPTORS IN CORNEAL NEW BLOOD VESSELS.THE EXPERIMENTS WERE PERFORMED ON WISTAR RATS, IN WHICH A MODEL OF CORNEAL NEOVASCULARIZATION WAS OBTAINED BY REPEATED INJECTIONS OF KETAMINE (150MG/KG BODY WEIGHT), ADMINISTERED INTRAPERITONEALLY. THE VARIATION OF THE EXTERNAL DIAMETER OF THE CORNEAL NEOFORMATION VESSELS WAS FOLLOWED, AT A TOTAL MAGNIFICATION OF APPROXIMATELY 400X, OVER 630 SECONDS. ADRENALINE PRODUCED STATISTICALLY SIGNIFICANT VASOCONSTRICTION IN THE CORNEAL NEOVESSELS VIA ALPHA-ADRENERGIC RECEPTORS. TIMOLOL PRODUCED STATISTICALLY SIGNIFICANT VASODILATION, REGARDLESS OF THE DOSE ADMINISTERED, BY A MECHANISM INDEPENDENT OF BETA-ADRENERGIC RECEPTORS. TIMOLOL CAUSED VASODILATION IN A DOSE-DEPENDENT MANNER, THE VASODILATION BEING INVERSELY PROPORTIONAL TO THE DOSE. FOLLOWING THESE RESULTS, WE CAN SAY THAT AT THIS LEVEL THERE ARE ALPHA-1 ADRENERGIC RECEPTORS, BUT WE CAN NOT EXCLUDE THE EXISTENCE OF BETA-ADRENERGIC RECEPTORS WHOSE STIMULATION PRODUCES VASODILATION.

  • Issue Year: 21/2021
  • Issue No: 1
  • Page Range: 53-66
  • Page Count: 14
  • Language: English
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