MMRP (MISMATCH REPAIR PROTEINS) AND SURVIVIN IN TUBULAR COLON ADENOMAS
MMRP (MISMATCH REPAIR PROTEINS) AND SURVIVIN IN TUBULAR COLON ADENOMAS

Summary/Abstract: Objective: The aim of our study was to observe the immunohistochemical expression pattern of mismatch repair proteins (MMRP), mutl homolog 1 (MLH1), mutl homolog C 2( MSH2), mutl homolog C 6 (MSH6) and mismatch repair endonuclease 2 (PMS2), as well as survivin, in colon polyps. Methods: We assessed above mentioned proteins in a unified group of 124 tubular adenomatous colon polyps with regard to the presence of dysplastic abnormalities in order to explore their relationship. Furthermore, we studied their relation to such clinicomorphological parameters as the age of patients, size of adenoma, degree of dysplastic changes, and localization of the lesion. Results: Survivin was expressed in 97 cases (78.2%), MLH1 was found in 111 cases (89.5%), MSH2 in 115 cases (92.7%), MSH6 in 118 cases (95.2%) and PMS2 in 105 cases (84.7%). The majority of absent MMRP cases was detected where the adenoma size was less than 10 mm with LGD (low-grade dysplasia). Survivin expression significantly correlated with the adenoma size and dysplasia grade. Subcellular survivin compartmentalization was statistically associated with the adenoma size, dysplasia grade and adenoma localization. Furthermore, we confirmed a significant relation between survivin expression and MMRP. In general, the intensity of immunoreaction was stronger in the MMRP than in survivin. Conclusions: Our recent results suggest that MMRP may suppress the antiapoptotic activity of survivin in LGD and HGD (high grade dysplasia) colon adenomas.

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