NEW CLASSIFICATION OF LOW GRADE MALIGNANT CARTILAGE MATRIX-PRODUCING BONE TUMOURS AND THEIR BRIEF MORPHOLOGICAL DIFFERENTIAL DIAGNOSIS
NEW CLASSIFICATION OF LOW GRADE MALIGNANT CARTILAGE MATRIX-PRODUCING BONE TUMOURS AND THEIR BRIEF MORPHOLOGICAL DIFFERENTIAL DIAGNOSIS

Summary/Abstract: Introduction: The new edition of the WHO Classification of Tumours of Soft Tissue and Bone re-classifies cartilage matrix-producing bone tumours. Within malignant lesions, a group of locally aggressive lesions and malignant tumours has been specified. The group of G1 chondrosarcomas has changed the most. They are divided into atypical central/peripheral cartilaginous tumours and central/peripheral G1 chondrosarcomas. Core: Chondrosarcomas are malignant tumours of the hyaline cartilage, very often with myxoid changes, calcifications or ossification, but without the bone formation. The local recurrence of low grade chondrosarcomas is determined by the adequacy of surgical resection of the tumour – the so-called complete tumour resection does not affect the histological grade. The histological grade determines the risk of distant metastasis. Conclusion: Despite the new classification, the morphological diagnosis of benign and malignant cartilage matrix-producing bone tumours has remained very challenging. In terms of diagnosis in practice, virtually all chondromatous tumours should be considered as chondrosarcomas until the benignity of given lesions is demonstrated.

• Details
• Contents