Syndróm lepivých doštičiek ako rizikový faktor trombofílie – kazuistiky a prevalencia
Sticky Platelet Syndrome as a Risk Factor for Thrombophilia - Case Reports and Prevalence

Summary/Abstract: Introduction: Thrombophilia is the presence of constitutive or acquired factors predisposing to thrombosis. Sticky platelet syndrome is a congenital prothrombotic condition due to a genetic disorder of blood composition. it is associated with platelet hyperagregability caused in response to induction of aggregation. Clinical signs, mostly arterial thrombosis, are common at a young age. Complications in pregnancy are also common. The basic treatment is antiplatelet medication. Aim: The aim of the work are retrospective case studies - case studies, which aim to evaluate the complex of thrombophilia diagnosis and characterize the prevalence of sticky platelet syndrome and risk factors for thrombophilia in the selected workplace. Results: Case reports of thrombophilia risk factors document the need for a broad diagnosis including medical history, clinical presentation, and laboratory tests. The spectrum of thrombophilia risk factors is characterized in the selected workplace as the most common risk factor F v Leiden, followed by pS deficiency, prothrombin mutation and increased F viii level. The proportion of sticky platelet syndrome is 4.41%. Conclusion: despite its limits, the work confirms the need for complexity in the diagnosis of thrombophilia and the relative representation of risk factors in the selected workplace, depending on the available literature.

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