Spektroskopická charakterizace peptidů a polypeptidů pro podporu růstu svalové hmoty
Spectroscopic characterization of peptides and polypeptides to promote muscle mass growth

Summary/Abstract: Ghrelin is a hormone enhancing the drive to eat and is sometimes called a “hunger hormone”. In human organism, it binds to the receptor GHS-R1a, which leads to the release of the growth hormone. Growth hormone secretagogues (GHSs) are a group of compounds that interact with GHS-R1a receptor in a similar way to ghrelin and thus enhance rapid muscle growth. Although GHSs are listed in the World Anti-Doping Agency’s Prohibited List, they have been abused by professional and amateur sportsmen and bodybuilders. The current situation demands development of reliable analytical methods for clear and rapid identification of these substances. In this work, the electronic circular dichroism spectroscopy is presented as an innovative, fast and reliable method for the analysis of GHSs group peptides.

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