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Summary/Abstract: Jesper Hoffmeyer is undoubtedly a classic of semiotics. His masterpieces Signs of Meaning in the Universe (1996) and Biosemiotics: An Examination into the Signs of Life and the Life of Signs (2008), belong to the bedrock of contemporary biosemiotics, an area of research in which Sebeok and Hoffmeyer have been my main sources of information and inspiration since 1990, when we first met at the occasion of one of the legendary Glottertal Colloquia. Specifically, Hoffmeyer deserves a place of honour in the history of biosemiotics for his firm semiotic stance against a scientific milieu which, rooted in the dualistic ‘two-cultures’ paradigm, has too long insisted on separating the study of nature from the study of mind, “encouraging scientists to de-semiotize all the naturally communicative and fundamentally interactive processes of living systems” (Hoffmeyer 2008: xiv).

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