THE ROLE OF NEUTROPHILS AND THEIR APOPTOSIS IN THE RESOLUTION OF INFLAMMATION
THE ROLE OF NEUTROPHILS AND THEIR APOPTOSIS IN THE RESOLUTION OF INFLAMMATION

Summary/Abstract: Inflammation, as a part of the body’s immune response, is presentin the progression of most diseases. Neutrophils form thefirst line of the defense against invading pathogens and subsequentlyplay a prominent role in the resolution of inflammation.They have a protective function as they release antibacterialenzymes and generate reactive oxygen species. Neutrophilsare able to regulate the inflammatory reaction by undergoingapoptosis. Apoptosis, then, facilitates cellular homeostasis( immune defense), promotes the elimination of activatedcells of the immune system, and can act as a major pathogeneticlink of an inflammation process, defining its character.This review highlights the mechanisms of apoptosis, theinfluence of external and internal factors and infectious agents(viruses, extracellular and intracellular microorganisms) on theenactment of neutrophil programmed death and the resolutionof inflammation.

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