ETIOLOGY AND DRUG SUSCEPTIBILITY OF BACTERIAL AGENTS INVOLVED IN ACUTE AND CHRONIC SINUSITIS
ETIOLOGY AND DRUG SUSCEPTIBILITY OF BACTERIAL AGENTS INVOLVED IN ACUTE AND CHRONIC SINUSITIS

Summary/Abstract: RECOGNITION OF THE UNIQUE MICROBIOLOGY OF CHRONIC SINUSITIS AND ANTIMICROBIALSUSCEPTIBILITY IS VERY IMPORTANT FOR SELECTING ANTIMICROBIAL THERAPY. THE AIM OF THISSTUDY WAS TO DETERMINE THE ETIOLOGY AND ANTIBIOTIC SUSCEPTIBILITY OF THE BACTERIACAUSING ACUTE AND CHRONIC SINUSITIS. THE STUDY GROUP INCLUDED 111 BACTERIAL STRAINSISOLATED FROM SINUS PUNCTURE OBTAINED FROM 150 PATIENTS HOSPITALIZED AT COUNTYCLINICAL EMERGENCY HOSPITAL, CRAIOVA, ROMANIA FROM 01.01.2014 TO 01.01.2016. THE ISOLATESWERE IDENTIFIED BY CONVENTIONAL MICROBIOLOGICAL PROCEDURES. ANTIMICROBIALSUSCEPTIBILITY TESTING WAS DETERMINED BY DISK DIFFUSION METHOD ON MUELLER-HINTON AGAR(BIOMERIEUX, USA) FOLLOWING CRITERIA AS RECOMMENDED BY THE CLINICAL AND LABORATORYSTANDARDS INSTITUTE (CLSI, DENVER, USA). THE PREVALENCE OF BACTERIAL AGENTS WAS:PSEUDOMONAS AERUGINOSA STRAINS 24 (13,11%), STAPHYLOCOCCUS STRAINS FOR S.AUREUS AND S.EPIDERMIDIS 26 (14,20%) RESPECTIVELY 47 (25,68%) AND ACINETOBACTER BAUMANNII STRAINS 14(7,65%). OF ALL P. AERUGINOSA CULTURED, 83.33% WERE RESISTANT TO CIPROFLOXACIN AND 97.92%SENSITIVITY TO COLISTIN. OF THE 26 STRAINS OF STAPHYLOCOCCUS AUREUS , 10 (38,46%) WERE MRSA AND 16 (61,54%) MSSA. IN TERMS OF THE SPECTRUM OF SENSITIVITY - THE MOST SENSITIVE DRUG WASLINEZOLID (96.15%) AND RESISTANT 84.62%, TETRACYCLINE. STAPHILOCCOCUS EPIDERMIDIS STRAINS,47 (25,68%) WERE RESISTANT TO TETRACYCLINE (91.49%) AND AN INCREASED SENSITIVITY TOMOXIFLOXACIN (78.72%), VANCOMYCIN (82.97%). FOR ACINETOBACTER STRAINS MOST EFFECTIVEANTIBIOTIC COLISTIN WAS (85.71%) AND INCREASED RESISTANCE TO CIPROFLOXACIN (64.29%). ANTIMICROBIAL RESISTANCE IS INCREASING IN CHRONIC AND ACUTE BACTERIAL SINUSITIS. THEEMERGENCE OF MRSA AND GRAM NEGATIV BACTERIA CAUSING CHRONIC SINUSITIS IS INCREASING.

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