NON-MUSCLE INVASIVE BLADDER CANCER RECURRENCE RISK FACTORS
NON-MUSCLE INVASIVE BLADDER CANCER RECURRENCE RISK FACTORS

Summary/Abstract: TO ESTABLISH THE RISK OF TUMORAL RECURRENCE FOR NON-MUSCLE INVASIVE BLADDER CANCER (NMIBC) DEPENDINGON HISTOLOGICAL OR ENVIRONMENTAL FACTORS. THE AIM OF THIS PAPER IS TO IMPROVE THE STANDARD CLINICAL CARE IN NMIBC PATIENTS FOLLOW-UP.WE INITIALLY EVALUATED 987 PATIENTS DIAGNOSED WITH BLADDER CANCER BETWEEN JANUARY 2005 AND DECEMBER 2014. MUSCLE-INVASIVE BLADDER CANCER (MIBC) WAS DIAGNOSED FOR 309 PATIENTS (31.3%) WHILE 678 (68.7%) HAD NMBIC. A TOTAL OF 540 PATIENTS WITH NMIBC WERE ANALYZED IN THE STUDY, WHILETHE OTHER 138 (20.4%) WERE EXCLUDED DUE TO INCOMPLETE CLINICAL DATA OR FOLLOW-UP. THE RETROSPECTIVE STUDYANALYZED PATIENTS’ CHARTS, DISCHARGE NOTES, ONCOLOGY REPORTS. PATIENTS WITH AT LEAST 3 YEARS COMPLETEFOLLOW-UP DATA WERE ENROLLED.THE AVERAGE AGE OF DIAGNOSED PATIENTS WITH NMIBC WAS 65.3 YEARS. THEMAJORITY OF PATIENTS WERE DIAGNOSED WITH SINGLE TUMORS (68.5%). NMIBC WAS PREDOMINANT IN MALES, WITH A SEXRATIO 3.25:1 FOR MALES. BLADDER TRIGON IS THE MAIN LOCATION FOR BLADDER TUMORS. SMOKING WAS THE MAIN RISKFACTOR ACCORDING TO OUR RESULTS. SMOKERS HAD A 4 TIMES HIGHER RISK FOR NMIBC DEVELOPMENT. PATIENTS WITHMULTIPLE BLADDER TUMORS HAD 2.28 HIGHER RISK OF RECURRENCE. OVERALL RECURRENCE FOR NMIBC WAS 49.1%.SMOKING IS THE MOST IMPORTANT RISK FACTOR AND THE RECURRENCE RATE IS HIGHER IN SMOKING-PATIENTS.ALSO,PATIENTS WITH MULTIPLE TUMOURS HAVE BEEN DIAGNOSED WITH HIGHER RISK FOR TUMOR RECURRENCE (P<0.05). LARGETUMORS AND PATIENTS WITH ASSOCIATED UROLOGICAL CONDITIONS HAVE HIGHER RISK OF TUMORAL RECURRENCE (OR =2.2).

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