Sonochemical Synthesis of 4-Aminoantipyrine Schiff Bases A Nd Evaluation of Their Antimicrobial, Anti-Tyrosinase and DPPH Scavenging Activities
Sonochemical Synthesis of 4-Aminoantipyrine Schiff Bases A Nd Evaluation of Their Antimicrobial, Anti-Tyrosinase and DPPH Scavenging Activities
Author(s): Maya G. Chochkiva, Boyka Stoykova, Iva Romanova, Petranka Petrova, Iva Tsvetkova, Hristo Najdenski, Lubomira Nikolaeva- Glomb, Nadya Nikolova, Galya Ivanova, Atanas Chapkanov, Tsenka Milkova, Martin Štícha, Ivan NemecSubject(s): Social Sciences, Education, Essay|Book Review |Scientific Life, Vocational Education, Higher Education , History of Education, Scientific Life, Conference Report
Published by: Национално издателство за образование и наука „Аз-буки“
Keywords: 4-aminoantipyrine; Schiff bases; mushroom tyrosinase; antimicrobial activity; DPPH scavenging activity
Summary/Abstract: A series of 4-(substituted benzylidene-amino)-2,3-dimethyl-1-phenyl-3-pyrazoline-5-ones (3a-l) was obtained using sonochemical assisted reaction. The synthesized Schiff bases were evaluated for their antiviral, antibacterial, anticandida, DPPH scavenging and anti-tyrosinase activities in vitro. The antimicrobial screening results revealed that amongst the tested imines, compound 3l appeared to be а promising one (with a minimal inhibitory concentration 47 ug/ml). The most potent DPPH scavengers were azometines 3a and 3g. No significant inhibition on the monophenolase activity in vitro of mushroom tyrosinase was observed.
Journal: Химия. Природните науки в образованието
- Issue Year: 27/2018
- Issue No: 6
- Page Range: 897-914
- Page Count: 18
- Language: English
- Content File-PDF