ALTERATION OF SEROTONIN POSITIVE CELLS IN COLONIC MUCOSA OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE
ALTERATION OF SEROTONIN POSITIVE CELLS IN COLONIC MUCOSA OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Summary/Abstract: BACKGROUND AND AIMS: THERE HAVE BEEN DESCRIBED INCREASED MUCOSAL DENSITIES OF SEROTONIN POSITIVE NEUROENDOCRINE CELLS IN INFLAMMATORY BOWEL DISEASE (IBD) . THE AIM OF OUR STUDY IS TO DETERMINE THE SEROTONIN POSITIVE NEUROENDOCRINE CELLS DENSITIES IN COLONIC MUCOSA OF PATIENTS WITH IBD.METHODS: COLONIC BIOPSIES FROM 18 PATIENTS WITH IBD ( 8 ULCERATIVE COLITIS; 10 CHRON’S DISEASE) AND 16 HEALTHY CONTROLS WERE EVALUATED HISTOPATOLOGIC WITH HEMATOXYLIN-EOSIN AND IMMUNOHISTOCHEMICAL WITH SEROTONIN ANTIBODIES.RESULTS: NE CELLS POSITIVE FOR 5-HT WERE COUNTED ON A TOTAL MEDIAN NUMBER OF 20.7 (1;80) CRYPTS IN IBD GROUP AND 25.65(2;64) CRYPTS IN CONTROLS.THE TOTAL DENSITIES/SUBJECT OF 5-HT POSITIVE CELLS WERE SIGNIFICANTLY HIGHER IN IBD GROUP COMPARED TO CONTROLS: 0.56(0.11;1.87) FOR IBD GROUP AND 0.28(0.14;0.71) FOR CONTROLS; P=0.004.CONCLUSION: OUR STUDY SHOWED AN INCREASED DENSITY OF SEROTONIN POSITIVE NEUROENDOCRINE CELLS IN IBD COLITIS WHEN COMPARED TO HEALTHY CONTROLS.

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