OBESITY AS A CIVILIZATION DISEASE AND RISK FACTOR FOR BREAST CANCER
OBESITY AS A CIVILIZATION DISEASE AND RISK FACTOR FOR BREAST CANCER

Summary/Abstract: Introduction: Obesity belongs to civilization diseases and is a risk factor for the occurrence of a number of serious diseases, including colon and breast carcinoma. At present, the effect of endogenous estrogen on breast cancer is examined. Core: We rely on an overview of known risk factors for breast cancer, hormone factors, and estrogen release from adipose tissue. The aim of the work is to clarify the hormonal mechanisms and to contribute to the understanding of the effect of estrogen on the development of breast carcinoma. Secondary prevention could be more effective in preventing breast cancer, especially in menopausal and postmenopausal women. Estrogen has a wide range of secondary metabolites. These secondary metabolites affect all estrogen-sensitive tissues, including breast. They act on them by stimulating estrogen receptors (ER), leading to the activation of estrogen-sensitive DNA genes. These genes are involved in cell growth, proliferation, apoptosis and carcinogenesis. The mammary gland epithelial cells respond to estrogens produced by aromatase in fatty tissue, including the stromal component of the breast itself. Epidemiological studies show that the long-term effect of estrogen increases the risk of malignant breast cancer, as well as benign breast cancer. Discussion: The topic of breast cancer and its etiopathogenesis, the possible influencing of factors should be constantly studied. This work incorporates as much knowledge as possible from different studies, but it is not easy to clarify this issue at all. Studies on estrogens are unclear in conclusions.

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