UTICAJ FARMAKODINAMSKIH PARAMETARA NA SUDBINU ANTIBIOTIKA
THE INFLUENCE OF PHARMACODYNAMIC PARAMETERS ON LIFE OF ANTIBIOTIC

Summary/Abstract: Introduction. When treating bacterial infections, one of the most important things, the main stone in the treatment, is optimal dosing of antibiotic. Core In the past, pharmacokinetic parameters, mainly C max, T max were the only ones that determined dosing od antibiotics. In the last two decades it was recognised that pharmacodynamic parameters- way of killing the bacteria as well as the presence and duration of postantibiotic effect- significantly influence the dosing of antibiotics. The most important examples are ampicillin- semisynthetic penicillin, and cefaclor, second generation cefalosporine antibiotic. For cefaclor, during lounching, producers recommended longer than optimal period between the doses, without increasing the dose. As a consequence, rapir resistence developed, and cefaclor, otherwise good antibiotc, is being in the proces of withdrawing from the market.

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