Полиелектролитни комплекси между хитозан и алгинат, получени чрез смесване при инжекторно разпръскване
Chitosan/Alginate Complexes Prepared by Jet Mixing

Summary/Abstract: The influence of mixing procedure on the size of polyelectrolyte complexes (PECs) was investigated using modified jet mixing complexation technique. Two natural weak polyelectrolytes – chitosan and alginate were used for PECs formation. All the experiments were done with 0.1% solution of the polyelectrolytes in acetate buffer with pH 5 and ionic strengths 0.1 M. The average particle diameter was determined by the method of dynamic light scattering using the Microtrac Nanotrac Wave Particle Size, Zeta Potential and Molecular Weight Analyzer. It has been found that decreasing the diameter of the outlet tube, which brings PEC out from the mixing chamber, and increasing its length, reduces the average diameter of the complex that is in the nano-size range. Mixing at a higher pressure in the chamber, which depends on the open state of the jets at the same tube geometry, also results in the formation of smaller PECs. Possible explanation for the observed phenomenon could be the tendency of PEC to aggregate at lower velocities and longer mixing times

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