Concentration of triacylglycerols and cholesterol in liver, kidneys and muscles of mice following exposure to ethyl alcohol
Concentration of triacylglycerols and cholesterol in liver, kidneys and muscles of mice following exposure to ethyl alcohol

Summary/Abstract: Introduction and aim. The effect of ethyl alcohol on biochemical transformations oftriacylglycerols is a widely discussed research problem. It may have practical importance formedicine and veterinary practice and procedures. The aim of the study was to assess the effectof specified doses of ethyl alcohol on the concentration of triacylglycerols and cholesterol inthe liver, kidneys, and thigh muscles tissue in experimental mice selectively bred for high andlow analgesia.Material and methods. The experiment was conducted on mice selected for high (HA) and low(LA) analgesia. They were given specified doses of ethyl alcohol to assess the effect of alcoholon triacylglycerols and cholesterol concentration in the liver, kidneys, and thigh muscletissues. It was measured by spectrofotomeric method.Results. A significant (p<0.05) increase of triacylglycerols was observed in the liver in both theHA and LA groups. However, in the muscle of LA the level of triacylglycerols after exposure toalcohol per os was significantly (p<0.05) lower vs. control values. Ethyl alcohol did not affectrenal function. The level of cholesterol in the liver of control HA animals was significantly(p<0.05) exacerbated, with respect to LA animals.Conclusions. Observed changes, induced by the effect of alcohol and a varied level of analgesia,may be the result of adaptation response in order to maintain the systemic physiologicalhomeostasis.

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