Studying the effects of Salvia spp. extract in a valproic-acid induced rat model of autism and its possible metabolic relevance
Studying the effects of Salvia spp. extract in a valproic-acid induced rat model of autism and its possible metabolic relevance

Summary/Abstract: Autism or autism spectrum disorder (ASD) is a human neuropsychiatric disorder with socialand communication difficulties. Medicinal plants have a diversified and inexhaustibletherapeutic potential. The aim of this study was to evaluate potentials of Salvia spp. essentialoils on rat model of ASD memories. Social interaction test was used to confirm that ratstreated with valproic acid have produced rats with autism spectrum disorder. Y-maze taskand Radial arm-maze task were used to evaluate the effects of salvia spp. essential oils on ratwith ASD memory. The most time spent by the rat in the empty box (25.33 ± 8.55 s) and theleast time (58.53±6.07 s) spent with the new rat by the test rat compared to the control rat,showed that valproic acid had an effect on pregnant rats who gave pups with ASD. Thepercentage of spontaneous alternation increasing in Y-maze for rats with ASD treated withSalvia spp. essential oil (79.27+ 3.08%; P = 0.03, F=6.29) compared to control rats and ratstreated only with valproic acid showed that Salvia spp. essential oil significantly improvedshort-term memory in rats and corrected rat learning memory. This research showed thatSalvia plant extracts have shown in vivo pharmacological properties and have proven themerits of various traditional uses of these plants in psychiatric disorders.

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