A current perspective on the relevance of nano and microplastics in the neurodevelopmental disorders: further relevance for metabolic, gastrointestinal, oxidative stress-related and zebrafish studies
A current perspective on the relevance of nano and microplastics in the neurodevelopmental disorders: further relevance for metabolic, gastrointestinal, oxidative stress-related and zebrafish studies

Summary/Abstract: Modern world is relying more and more on the use of plastics in order to conduct our daily tasks going from the simple lid that covers our morning coffee to large scale use in packaging and buildings. But how does the use of so much plastic influence human’s normal growth and development or more importantly, how does it affect the brain functions? For the purpose of this paper of giving a little literature insight over the toxic effects of micro-/nanoplastics we chose to approach it from a multidisciplinary point of view with a focus on the use of zebrafish as animal models; ranging from how microplastics disrupts the host eubiosis and gradually provokes an impairment along the gut-brain axis (GBA) in both mice and zebrafish to nanoplastics inducing oxidative stress status which furthermore leads to increased mortality and brain cells apoptosis. Nanoplastics has also been reported as being transferred from mother to offsprings causing a series of morphological and physiological changes, as well as neurotransmitters inhibitions (dopamine, oxytocin, serotonin) in zebrafish fish as several studies have suggested.

• Details
• Contents