ИЗПОЛЗВАНЕ НА СЪВРЕМЕННИ OMICS - ТЕХНОЛОГИИ ЗА ОЦЕНКА НА ТОКСИЧНОСТТА НА ОКОЛНАТА СРЕДА БЛИЗО ДО УРАНОВИТЕ МЕНИ В КАЗАХСТАН
APPLICATION OF MODERN OMICS – TECHNOLOGIES TO ASSESS THE TOXICITY OF THE ENVIRONMENT NEAR THE URANIUM MINES IN KAZAKHSTAN

Author(s): Anuarbek Kakabyaev
Subject(s): Information Architecture, Electronic information storage and retrieval
Published by: Бургаски свободен университет
Keywords: uranium radiation; chromosome aberrations; polymorphism of GSTM1 and GSTTI genes; radionuclides; uranium; uranium-degradation products; uranium mining enterprises; mutagenicity; chromosomal aberration
Summary/Abstract: The Kazakhstan is characterized by number of factors that define anthropogenic and natural manifestations of increased radioactivity the main of which are numerous sites of abnormal increases in natural radioactivity, uranium deposits, and ore. Long-term and large-scale activities of uranium mines and mining enterprises of other minerals associated with uranium mineralization have negative impact on public health. It has not been determined the radiation dose that people of Central Asia gets from radionuclides of uranium, a high level of radon in the contaminated areas. In the present study, uranium mine-workers in the Stepnogorsk mining-milling complex in Northern Kazakhstan were investigated for the expression of chromosome aberrations and for genetic factors that can modify the exposure-related expression of chromosome damage.The study suggests that uranium mine-workers in Northern Kazakhstan have excessive exposure that can cause an increased risk for health consequences such as cancer. In addition, GSTM1 and/or GSTT1 null genetically susceptible individuals may have higher health risk.

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