STRATÉGIA CHIRURGICKEJ LIEČBY HEPATÁLNYCH METASTÁZ KOLOREKTÁLNEHO KARCINÓMU
STRATEGY OF SURGICAL TREATMENT OF COLORECTAL LIVER METASTASES

Summary/Abstract: Introduction: Colorectal cancer liver metastases (CLM) accounts for most frequent indication for liver resection in our geographic region. It is reported that approx. 50% of patients diagnosed with colorectal cancer possess liver metastases. In the time of initial CRC diagnosis 20-25% of patients are already found in the fourth stage of the disease. Liver limited metastases are present in 70-80% of cases. Core of work: Prognosis of untreated patients is poor. One-year survival is reported less than 30% a nd l ess t han 5 % s urvive 5 years a fter C RC d iagnosis establishment. In the case of resectable case of CLM surgical resection represents an optimal treatment modality with 5- years survival reaching 28-58% after curative resection. However only 15-25% of CLM patients are regarded resectable. We are witnesses to indication criteria expansion, all patients in whom radical R0 resection is possible with concurrent preservation of adequate liver remnant are becoming candidates for liver resection. Conclusion: Nowadays multidiciplinary management of metastatic colorectal cancer patients has become a standard. Neoadjuvant systemic treatment can increase the number of candidates for major hepatic resections that had been intitially considered nonresectable.

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